Time-Based Biases | Understanding Medical Research

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Immortal time bias, lead-time bias, and length-time bias all come from the same mistake: letting information from the future leak into the start of a study. This video covers how to spot each one and the rule to never use future information in a statistical model. Chapters: 00:00 Time-based biases 00:34 The survival stone study 02:47 Academy Award winners and immortal time 05:43 Self-monitoring blood glucose 07:52 Never use future information 09:44 Lead-time bias 12:23 Length-time bias 13:59 Take-home points Learning objectives: After watching, you'll be able to: - Define immortal time bias, lead-time bias, and length-time bias - Trace how assigning future information at baseline makes an ineffective treatment look protective - Explain how baseline-only data, time-varying analysis, and randomization each remove a time-based bias 📺 Watch the full playlist on YouTube: https://www.youtube.com/playlist?list=PLh9mgdi4rNewVyTec_MVGxIbNSEeMhEsZ 🎓 Enroll on Coursera for assessments and a certificate: https://www.coursera.org/learn/medical-research 🌐 Explore more learning opportunities on Yale Online: https://online.yale.edu/courses/understanding-medical-research-your-facebook-friend-wrong

Published 2020-07-31 · Watch on YouTube ↗
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