How do brains wire up?

From the creator

The brain is made up of billions of nerve cells, or neurons, wired together in a highly complex and organised way. But how do they know where to go when the brain is developing? These remarkable time-lapse movies capture the journey of living neurons in the frog brain. Narrated by Professor Christine Holt, these movies show some of the discoveries of her research group in the Department of Physiology, Development and Neuroscience. Movie credits: Sonia Witte, Trina Lu Bo, Hanno Svoboda and Christine Holt Read more: @/journeys-of-discovery-wiring-the-brain Holt, C.E. and Harris, W.A. Order in the initial retinotectal map in Xenopus: A new technique for labelling growing nerve fibers. Nature 301:150-152 (1983) Harris, W.A., Holt, C.E. and Bonhoeffer, F. Retinal axons with and without their somata, growing to and arborizing in the tectum of Xenopus embryos: A time-lapse video study of single fibers in vivo. Development 101:121-133 (1987) Nakagawa, S-i., Brennan, C., Johnson, K., Shewan, D., Harris, W.A. and Holt, C.E. Ephrin-B regulates the ipsilateral routing of retinal axons at the optic chiasm. Neuron 25: 599-610 (2000) Campbell, D.S. and Holt, C.E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32: 1013-1026 (2001) Leung, K-M., van Horck, F.P.G., Lin, A.C., Allison, R., Standart, N. and CE. Holt, C.E.Asymmetrical b-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nature N

Published 2023-10-18 · Watch on YouTube ↗
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