Fischer Indole Synthesis

From the creator

We've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer indole synthesis in 1882 to do precisely this, using aryl hydrazines and ketones. What's the mechanism? Is that a sigmatropic shift you spot in there? Yes it is! It's a fun one, check it out. Watch the whole Organic Chemistry playlist: http://bit.ly/ProfDaveOrgChem General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem Biology Tutorials: http://bit.ly/ProfDaveBio Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1 Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2 Mathematics Tutorials: http://bit.ly/ProfDaveMath EMAIL► [email protected] PATREON► http://patreon.com/ProfessorDaveExplains Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience! Amazon: https://amzn.to/2HtNpVH Bookshop: https://bit.ly/39cKADM Barnes and Noble: https://bit.ly/3pUjmrn Book Depository: http://bit.ly/3aOVDlT

Published 2021-08-05 · Watch on YouTube ↗
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